US tennis ace Madison Keys has tested positive for COVID-19 and will miss the Australian Open in Melbourne.

The world No. 16 says she returned a positive result before she was due to travel to Australia and is now self-isolating at her home.

The first Grand Slam of the year is scheduled to begin on February 8.

“I’m very disappointed to not be able to play in the coming weeks after training hard in the off-season and knowing Tennis Australia and the tours did so much to make these events happen,” the 25-year-old tweeted.

Keys was a semi-finalist in Melbourne in 2015 and she made the final of the 2017 US Open.

Earlier, former world No.1 Andy Murray tested positive for the virus, putting his Australian Open campaign in doubt.