Lumen Field will play host to Monday's Round 1 NFL game between Seattle Seahawks and San Francisco 49ers. The game kicks off at 6:05 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Seattle Seahawks vs. San Francisco 49ers game and give you our free tips and bets.
When: Monday September 8, 2025 at 6:05 am
Where: Lumen Field
Bet 💰: Bet On This Match HERE
Seattle Seahawks vs San Francisco 49ers Odds
Seattle Seahawks vs San Francisco 49ers Preview
San Francisco is expected to bounce back in a big way after enduring a season from hell in terms of injuries in 2024.
But Im not buying into that revival narrative, their roster is still lacking the talent needed to really compete at an elite level, especially on offence.
Christian McCaffrey is back after missing all bar four games in 2024 and might be the only real cause for optimism because he and tight end George Kittle are going to have to do it all themselves.
It is going to be tough sledding against a Seattle defence that has the potential to be a top-five unit in the NFL.
Happy to take the Seahawks as underdogs at their current price, they look primed for the upset.
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Head To Head Bet
We're tipping San Francisco 49ers to win at $1.72 odds.
