Australian wildcard Jordan Thompson has pulled off the biggest victory of his blossoming tennis career by upsetting Spanish eighth seed David Ferrer at the Brisbane International.

Thompson will now play his first ATP quarterfinal against world No.5 Kei Nishikori after fighting back to defeat Ferrer 4-6 7-5 7-5 at Pat Rafter Arena.

The Sydney 22-year-old, ranked 79th in the world, gave up a break in both the second and third sets to the former French Open finalist before finally taking the win with his fifth match point.