Frenchman Lucas Pouille has become to first men’s seed to fall at the Brisbane International, surrendering in the second round due to a foot injury.

Pouille was trailing Brit Kyle Edmund 6-3 3-1 when he called it quits midway through the second set after already receiving treatment for blisters.

The world No.14 was leading 1-0 during the medical break when he had the toes and front of his right foot heavily strapped but he the lost the next three games before retiring.

Pouille, the sixth seed, was forced to back up on show court one 24 hours after coming back from 0-5 down to beat compatriot Gilles Simon in two tie-break sets on Tuesday.

Edmund is now likely to meet world No.4 and tournament second seed Stan Wawrinka, who plays Serb Viktor Troiki on Wednesday night, in the quarter-finals.

Third seed Kei Nishikori survived a scare, outlasting American qualifier Jared Donaldson in the Brisbane International second round on Wednesday.

The Japanese world No.5 finally held out the 20-year-old 4-6 6-4 6-3 after almost two and a half hours at Pat Rafter Arena.

Nishikori booked a quarter-final against the winner of Australian Jordan Thompson’s second round clash with eighth seed David Ferrer of Spain.

Nishikori, 27, quickly had to blow off rust against the young American after a first round bye.

The three-time Brisbane semi-finalist was on the back foot from the outset against the world No.105 who took the first set in under an hour.

Nishikori raced to a 3-0 lead in the second set, only for the American to level at 4-4 before the third seed broke again and served it out.

The Japanese star jumped to a 4-1 lead in the third and held on to deny the American young gun his first career quarter-final and a maiden win over a top-10 player.