The Queensland Reds have made three changes to their team for their final Super Rugby clash of the year against the Melbourne Rebels on Friday.

Veteran Wallabies tighthead prop Greg Holmes will return from injury to make a final appearance for the Reds after 12 years with the franchise before joining English club Exeter.

Injury has forced the other changes, with prop James Slipper (sternum) and fullback Jack Tuttle (shoulder) replaced by Sef Fa’agase and Tom Banks respectively.