Levi's Stadium will play host to Monday's Round 4 NFL game between San Francisco 49ers and Jacksonville Jaguars. The game kicks off at 6:05 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the San Francisco 49ers vs. Jacksonville Jaguars game and give you our free tips and bets.

When: Monday September 29, 2025 at 6:05 am

Where: Levi's Stadium

Bet 💰: Bet On This Match HERE

San Francisco 49ers vs Jacksonville Jaguars Odds

San Francisco 49ers vs Jacksonville Jaguars Preview

The San Francisco 49ers (3-0) will take on the Jacksonville Jaguars (2-1) at Levi’s Stadium on Sunday, September 28. The 49ers could see the return of Brock Purdy at quarterback after missing two games due to a toe injury, giving their offense a boost alongside running back Christian McCaffrey. However, they’ll be without star pass rusher Nick Bosa, which could test their defensive depth.

The Jaguars, led by Trevor Lawrence, have struggled on the road this season and face a tough challenge against San Francisco’s strong defense. Home-field advantage and a solid defensive unit make the 49ers slight favorites, but the Jaguars’ offense could make it a close contest.