SoFi Stadium will play host to Monday's Round 4 NFL game between Los Angeles Rams and Indianapolis Colts. The game kicks off at 6:05 am with Los Angeles Rams heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Los Angeles Rams vs. Indianapolis Colts game and give you our free tips and bets.

When: Monday September 29, 2025 at 6:05 am

Where: SoFi Stadium

Bet 💰: Bet On This Match HERE

Los Angeles Rams vs Indianapolis Colts Odds

Los Angeles Rams vs Indianapolis Colts Preview

The Los Angeles Rams (2–1) host the Indianapolis Colts (3–0) at SoFi Stadium on Sunday, September 28. The Rams will rely on Matthew Stafford and rising star Puka Nacua, while the Colts aim to continue their perfect start under Daniel Jones. Key battles include Aaron Donald vs the Colts’ offensive line and both defenses trying to contain each other’s passing game. The game is expected to be close, with the Rams slightly favored at home.