Robin van Persie has confirmed Arsenal’s north London derby clash with Tottenham Hotspur will carry an extra edge by insisting it is a game Arsene Wenger’s side simply can’t afford to lose.

Local rivalry ensures the visit of Spurs to the Emirates Stadium is always highly charged.

But for the first time in many years, Harry Redknapp’s side go to the home of their rivals on Sunday as clear favourites to win – and with the Gunners’ season in danger of imploding.

Wenger’s Arsenal team face their near neighbours having exited the FA Cup at the hands of Sunderland and been all but eliminated from the Champions League after losing their last 16 first-leg tie with AC Milan 4-0.

That means a top-four finish, and with it a place in next season’s Champions League, is Arsenal’s only realistic chance of salvaging something from the season.

But with a 10-point gap between Wenger’s men and third-placed Spurs, and Chelsea, Newcastle and Liverpool all challenging strongly for fourth, van Persie knows there is no margin for error.

“They’re above us for the first time in many years but it’s in our hands to change the way things are going, win the game and start moving closer to them,” van Persie said.

“A draw will not be a good result for us, either in our bid to catch up with Spurs or in our efforts to fight off our other challengers for a Champions League place.”

Wenger has not given up hope of overhauling Spurs.

“You judge at the end of the season,” he said. “The only thing you can say is that in the last 15 years Spurs have finished behind Arsenal.”

Redknapp, meanwhile, made it clear that finishing above Arsenal and Chelsea would be a major achievement.

“It’s the most important thing this year to be honest,” he said. “I really want to be the top London club and at least keep that third place if we can.”

Redknapp should be able to welcome Luka Modric back from illness and Benoit Assou-Ekotto, Emmanuel Adebayor and Rafael van der Vaart from injury.

Adebayor, the former Arsenal forward, is likely to receive abuse from Arsenal supporters.

That had been the case at White Hart Lane earlier in the season and the on-loan Manchester City forward had previously taunted them with an elaborate goal celebration.