Serena Williams has marked her release from quarantine with a victory against Naomi Osaka in an exhibition match in Adelaide.

Williams and Osaka both ended their 14 days of hotel quarantine on Friday before playing at Memorial Drive.

Williams took the first set 6-2 before the reigning US Open champion hit back to take the second with the same scoreline.

The duo then played a super tiebreaker with Williams prevailing 10-7.

Williams and Osaka were among the tennis elite who had spent the past two weeks in quarantine at an Adelaide hotel.

Williams, at a brief pre-match media call, said she had been crossing off the 14 days of quarantine on a calendar, having spent the time with her three-year-old daughter Olympia.

“We went to the zoo,” Williams said when asked how she celebrated the end of quarantine.

“I am so glad it’s over because to be in a room with a three-year-old and being her best friend is definitely difficult, especially after training and working out.

“Honestly, I wouldn’t trade anything, spending hours and hours and hours with her was really fun.”

Williams’ sister Venus will meet Romanian Irina-Camelia Begu before the night session of the exhibition event featuring Australia’s world No.1 Ash Barty.