Fernando Verdasco upset second seed Rafael Nadal 6-4 2-6 6-3 on Sunday in a third-round match-up of Spaniards to advance at the Miami Open.
Nadal, a four-time Miami runner-up, leaves the Masters Series event without a title again this year after his 11th appearance.
Verdasco, ranked 29th, defeated Nadal for the second time in a row, although their prior match was three years ago in Madrid.
Nadal saved a match point in the eighth game of the second set trailing 5-2, but Verdasco closed out the shocker a game later with a return winner.