Marin Cilic, the 2014 champion, has won his US Open opening-round match against aptly named American Tennys Sandgren on Monday.

The fifth-seeded Cilic, in his first match since losing to Roger Federer in the Wimbledon final last month, dropped the third set on his way to a 6-4 6-3 3-6 6-3 victory.

Cilic has been nursing a left leg injury but managed to produce 55 winners against the 105th-ranked Sandgren.

Jo-Wilfried Tsonga made light work of Romanian Marius Copil in a routine 6-3 6-3 6-4 win for the French eighth seed.

John Isner, the highest-ranked American, delivered 22 aces and was broken only once in a 6-1 6-3 4-6 6-3 victory over Pierre-Hugues Herbert of France.

Spanish seeds had mixed results with Pablo Carreno Busta progressing to the second round while David Ferrer lost.

Carreno Busta, the 12th seed, was the first seeded player to progress to the next round after accounting for American qualifier Evan King 6-3 6-2 7-6 (7-5).

Ferrer, the 21st seed, won the first set against Mikhail Kukushkin but the Kazakh qualifier was too good after that point and won 4-6 6-3 6-2 6-1.

South African veteran Kevin Anderson, the 28th seed, beat American qualifier JC Aragone 6-3 6-3 6-1.

Diego Schwartzman, the Argentine 29th seed, overpowered his countryman Carlos Berlocq 6-2 6-1 6-3.

Kyle Edmund of Great Britain caused an upset with a 6-3 7-5 6-3 victory over Dutchman Robin Haase, the 32nd seed.

American Steve Johnson accounted for experienced Spaniard Nicolas Almagro 6-4 7-6 (7-2) 7-6 (7-5) while Frenchman Benoit Paire beat Lukas Lacko of Slovakia 6-3 6-2 7-6 (7-5).

Korean Chung Hyeon defeated Horacio Zeballos of Argentina 3-6 7-6 (10-8) 6-4 6-3 and Florian Mayer of Germany edged Rogerio Dutra Silva of Brazil 7-5 0-6 6-3 6-4.

Radu Albot of Moldova beat American Ernesto Escobedo 7-5 4-6 6-2 6-4.

British qualifier Cameron Norrie was two sets to the good when Russian opponent Dmitry Tursunov retired while Evgeny Donskoy of Russia was also the beneficiary of a retirement.