Samantha Stosur’s Wimbledon campaign ended, with 23rd-seeded German Sabine Lisicki coming from a set down to win their third-round match on Saturday.

The 14th seed missed a chance to reach the last 16 for the first time in her career in a 4-6 6-2 6-1 loss.

The defeat leaves Bernard Tomic as the last Australian standing in singles, after he beat French ninth seed Richard Gasquet earlier on Saturday.

Lisicki progressed to a possible fourth-round clash with top seed Serena Williams.

Stosur entered the match on Centre Court full of confidence having equalled her best performance at the grass-court grand slam with easy wins over Slovakian Anna Schmiedlova and Russian Olga Puchkova.

The 29-year-old always was prepared for a much tougher encounter against big-hitting Lisicki, a semi-finalist at Wimbledon in 2011 and quarter-finalist the past three years running.

Still Stosur started impressively, securing the first break of the game to go 2-1 up.

From there the Australian maintained a strong service game to wrap up the first set inside 28 minutes.

Lisicki lifted in the second set, breaking serve in the fourth game.

The German went 5-2 up before calling an injury timeout as she received treatment for a cut on her finger.

Stosur earned a break point the next game but Lisicki fought back to square the match at one set all.

Stosur faced a titanic struggle in her opening service game of the second set before eventually being broken.

She missed several chances to break back in the next game but fought back from 0-40 to hold serve shortly after to keep her fading hopes alive.

However, she ultimately couldn’t halt a fast-finishing Lisicki, with the German securing another break and serving out the match.