Lleyton Hewitt will take on countryman James Duckworth in the first round of his 20th and last Australian Open campaign.

Bernard Tomic, the men’s 16th seed, opens against Denis Istomin of Uzbekistan, and faces a potential fourth-round showdown with world No.2 Andy Murray.

Nick Kyrgios has drawn Spaniard Pablo Carreno Busta in his opener, while Australian women’s No.1 Samantha Stosur meets a qualifier first up.

Stosur could run into Monica Pueg, the Puerto Rican who knocked Australia’s one-time US Open champion out of the Sydney International this week, in round two and then fourth seed Agnieszka in round three.

Australian No.2 Daria Gavrilova faces Lucie Hradecka and could strike Czech sixth seed Petra Kvitova in the second round.

World No.1 and defending champion Serena Williams will launch her quest for a seventh title against Italian Camila Giorgi.