Australian Matthew Ebden has been eliminated from ATP San Jose Open after a straight-sets loss to South African sixth seed Kevin Anderson.

Anderson dispatched Ebden 6-1 6-2 on Thursday to book a quarter-final date against defending champion and third seed Milos Raonic of Canada.

Belgian Steve Darcis upset Czech fourth seed Radek Stepanek 7-6 (7-4) 7-6 (7-2) to also progress the quarter-finals of the $US531,000 event.

Darcis, ranked 72nd in the world, will next face the winner of a later match between French fifth seed Julien Benneteau and Luxembourg’s Gilles Muller.

In his 10th professional season, 27-year-old Darcis is seeking his third ATP title after a 2007 triumph in Amersfoort and a 2008 victory in Memphis.

French top seed Gael Monfils withdrew with a right knee injury and was replaced by US lucky loser Blake Strode, who was ousted by Bulgarian Dimitar Kutrovsky 7-5 6-3 in another second-round match.