Lleyton Hewitt is the last Australian standing at the ATP Tour’s Atlanta Open after Matthew Ebden was knocked out by South Africa’s Kevin Anderson, who claimed a quarter-final berth, on Thursday.

Ebden claimed the first set in a tie-break, before being run over in the remaining sets to go down 6-7 (7-9) 6-2 6-2.

Hewitt powered into the quarter-finals on Wednesday when he beat American wildcard Rhyne Williams to set up a showdown with Croatian Ivan Dodig.

The second-seeded Anderson will face Uzbekistan’s Denis Istomin following his defeat of fifth seed Lu Yen-Hsun 7-5 6-2.

Meanwhile, top seeded John Isner edged wild card Christian Harrison 7-6 (11-9) 4-6 7-5 to book his quarter-final berth.

The American fired 29 aces but needed two hours and 24 minutes to get past the tenacious 19-year-old, whose elder brother Ryan Harrison booked a quarter-final berth earlier in the day.

Ryan Harrison will play Colombian Santiago Giraldo who was leading Michael Russell 5-7 6-3 3-0 when the American retired from their match.

Isner will play compatriot James Blake, who reached his first quarter-final of the season with a brisk 6-3 6-2 victory over eighth-seeded Russian Evgeny Donskoy.

Blake broke Donskoy’s serve three times and saved all four break points he faced in the 64-minute encounter.

“I always feel like the hard-court summer is my best chance to get points, I’m playing my best tennis,” Blake said.

“The courts usually suit me the best. When it’s hot I play pretty well. Home crowds in the States, it’s generally my favourite time of the year. This is a good start to it right away.”