Six-time champion Novak Djokovic’s hopes of turning around his season at the Miami Open have ended in the second round, when he was defeated 6-3 6-4 by Frenchman Benoit Paire.

The loss on Friday snapped a 16-match winning streak in the tournament for the ninth-seeded Serbian, who had been eliminated in the second round at Indian Wells but said before the match his right elbow was pain-free for the first time in a long while.

He had won the tournament in 2014, 2015 and 2016 but missed last year’s event with the elbow injury.

Paire delivered nine aces to two for the Serb and won 71 per cent of his service points.

Meanwhile, second-seeded Croatian Marin Cilic moved into the third round with a 7-5 6-3 triumph over Frenchman Pierre-Hugues Herbert.

The early upsets did not end with Djokovic’s loss.

David Goffin was unsuccessful in his return from an eye injury, with the seventh seeded Belgian falling to Portugal’s Joao Sousa 6-0 6-1.

American wild card Michael Mmoh produced another surprise, upsetting 12th seeded Roberto Bautista Agut 7-6(4) 2-6 6-4.

Diego Schwartzman and Milos Raonic also moved on.

Argentine Schwartzman, the 13th seed, dominated Chilean Nicolas Jarry 6-3 6-1 while the 20th seeded Raonic, a 2016 Wimbledon finalist, cruised into the third round with a 6-3 6-3 victory over Swede Mikael Ymer.