Australian Jordan Thompson has bowed out of the Delray Beach Open, beaten in a second-round duel with Italian veteran Andreas Seppi.

World No.68 Thompson forced a deciding set after losing the opener before sixth seed Seppi broke twice in the last to prevail 6-3 4-6 6-1 in an hour and 46 minutes.

Countryman Nick Kyrgios is scheduled to play Radu Albot on Friday morning (AEDT) for a spot in the quarter-finals of ATP event in Florida.