Saracens prop Mako Vunipola is set to make his first start for Six Nations grand slam-chasers England against Italy at Twickenham on Sunday.
Vunipola was one of five changes announced on Friday by coach Stuart Lancaster to the team that beat France 23-13 at Twickenham last time out.
New Zealand-born of Tongan parents, Vunipola won his first seven rugby Test caps as a powerful replacement.
But the son of former Tonga hooker Fe’ao Vunipola has a chance to impress from kick-off, picked at loosehead in place of Joe Marler.
Elsewhere in the pack, Tom Youngs takes over from Dylan Hartley at hooker with Wasps flanker James Haskell back on the blindside in place of Courtney Laws.
England, who have never lost to Italy, go into their latest clash against the Azzurri with a new halves pairing.
Experienced five-eighth Toby Flood takes over from the injured Owen Farrell, out with a thigh strain suffered against France, and Danny Care gets a chance to start at halfback instead of Ben Youngs.
On the bench, Freddie Burns provides No.10 cover in Farrell’s absence while Leicester flanker Tom Croft returns to the Test scene 11 months after a broken neck nearly left him paralysed.
Lancaster had long intended to “freshen up” his team ahead of next weekend’s finale away to Wales while, at the same time, ensuring strength to prevent Italy, who threw the Championship wide open by beating France on the opening weekend, causing another shock.
“We were very happy with the way we finished the France game,” Lancaster said in a Rugby Football Union (RFU) statement.
“The impact the replacements made shows that we have competition for places across the board and we have had to make some tight calls.
“Italy will be highly motivated for this game and we will have to perform for the full 80 minutes. I am sure those starting will seize their chance and the bench will also have a significant part to play as the game goes on,” added Lancaster, bidding to guide England to a first grand slam since their World Cup-winning year of 2003.
They lead the table by two points from Scotland and Wales, who meet at Murrayfield on Saturday, and have a points difference advantage of plus 17 over the Welsh.
England (15-1): Alex Goode, Chris Ashton, Manu Tuilagi, Brad Barritt, Mike Brown, Toby Flood, Danny Care, Tom Wood, Chris Robshaw (capt), James Haskell, Geoff Parling, Joe Launchbury, Dan Cole, Tom Youngs, Mako Vunipola. Res: Dylan Hartley, David Wilson, Joe Marler, Courtney Lawes, Tom Croft, Ben Youngs, Freddie Burns, Billy Twelvetrees.