Argentina coach Daniel Hourcade has resigned after a second consecutive defeat by Wales left the team with two wins in 17 games.
“The players aren’t responding,” Hourcade told reporters after the 30-12 reverse in Santa Fe on Saturday.
“The responsibility is mine. The cycle is complete.”
Hourcade took over as coach in 2013 and led Argentina to the 2015 World Cup semi-finals.
But the Pumas have struggled since, failing to beat the traditional rugby powers and this month they lost two in a row to the Welsh, handing them their first Test series victory in Argentina since 1999.
Argentina play Scotland on Saturday in Resistencia.