Nissan Stadium will play host to Friday's Round 16 NFL game between San Francisco 49ers and Tennessee Titans. The game kicks off at 12:21 pm with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the San Francisco 49ers vs. Tennessee Titans game and give you our free tips and bets.

When: Friday December 24, 2021 at 12:21 pm

Where: Nissan Stadium

Bet 💰: Bet On This Match HERE

San Francisco 49ers vs Tennessee Titans Odds

San Francisco 49ers vs Tennessee Titans Preview

Week 16 will begin just two days after Week 15 finished as the busy holiday season continues with a crucial Thursday Night Football showdown between two playoff hopefuls, the Tennessee Titans and San Francisco 49ers.

The AFC-South-leading Titans could have virtually sealed the division title last week and even taken back the top seed in the AFC, but they were shut out in the second half, letting a double-digit lead slip in their 19-13 loss to the Steelers.

Meanwhile, the 49ers had no such problems, cruising to a 31-13 win over the Falcons, marking their fifth victory in six outings.

Quarterback Jimmy Garoppolo has proven the barometer, as the Niners have won each of the seven games he has avoided an interception, while losing five of the six in which he has thrown one.

It’s a possibly intimidating trend for a Tennessee defence that has recorded an interception in just one of its past five outings.

San Francisco 49ers vs Tennessee Titans Tip