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New York Giants vs San Francisco 49ers Tips, Odds & Predictions – NFL 2025

MetLife Stadium will play host to Monday's Round 9 NFL game between New York Giants and San Francisco 49ers. The game kicks off at 5:00 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the New York Giants vs. San Francisco 49ers game and give you our free tips and bets.

When: Monday November 3, 2025 at 5:00 am

Where: MetLife Stadium

Bet: Bet On This Match HERE

New York Giants vs San Francisco 49ers Odds

New York Giants vs San Francisco 49ers Preview

Despite the uncertainty over who will be starting at quarterback for San Francisco this weekend, it really doesn’t change much of the analysis and predictions.

Mac Jones has been a more than capable fill in for Brock Purdy and whichever one starts will be put in a good position to succeed here.

Especially against a Giants team that has had its moments but really failed to close out games when given the opportunity.

Not to mention they have to overcome the loss of Cam Skattebo who brought a real energy to their ground game.

San Francisco has been trading wins and losses for the last six weeks and I’ll happily back them to continue that trend with a victory here.

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San Francisco 49ers
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