Caesars Superdome will play host to Monday's Round 2 NFL game between New Orleans Saints and San Francisco 49ers. The game kicks off at 3:00 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the New Orleans Saints vs. San Francisco 49ers game and give you our free tips and bets.
When: Monday September 15, 2025 at 3:00 am
Where: Caesars Superdome
Bet: Bet On This Match HERE
New Orleans Saints vs San Francisco 49ers Odds
New Orleans Saints vs San Francisco 49ers Preview
Who honestly knows what were getting in this game, the 49ers have been hit hard by injury and it looks like Brock Purdy will not play.
The Saints were not as terrible as I expected last week against the Cards but I saw nothing that makes me think they can score big points on the 49ers defence.
If Purdy is a no go, Christian McCaffrey will be force fed. He is the only player I like in this game.
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Head To Head Bet
We're tipping San Francisco 49ers to win at $1.60 odds.