SoFi Stadium will play host to Friday's Round 5 NFL game between Los Angeles Rams and San Francisco 49ers. The game kicks off at 10:15 am with Los Angeles Rams heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Los Angeles Rams vs. San Francisco 49ers game and give you our free tips and bets.

When: Friday October 3, 2025 at 10:15 am

Where: SoFi Stadium

Bet 💰: Bet On This Match HERE

Los Angeles Rams vs San Francisco 49ers Odds

Los Angeles Rams vs San Francisco 49ers Preview

The NFC West rivalry reignites on October 3rd when the Los Angeles Rams face the San Francisco 49ers in a primetime clash. The 49ers, off to a strong start this season, continue to rely on their dominant defense and balanced offense led by Christian McCaffrey and Brock Purdy. Kyle Shanahan’s side has had the Rams’ number in recent years and will look to extend that dominance.

Los Angeles, however, has shown resilience with Matthew Stafford finding rhythm alongside star wideout Cooper Kupp and rookie sensation Puka Nacua. Aaron Donald remains the cornerstone of their defense, and his battle against San Francisco’s offensive line could prove pivotal.

With both teams chasing early-season momentum in one of football’s toughest divisions, expect a physical contest where turnovers and red-zone execution could decide the outcome. This rivalry rarely disappoints — and Friday night should be no exception.

Los Angeles Rams vs San Francisco 49ers Tip