Lucas Oil Stadium will play host to Tuesday's Round 16 NFL game between Indianapolis Colts and San Francisco 49ers. The game kicks off at 12:15 pm with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Indianapolis Colts vs. San Francisco 49ers game and give you our free tips and bets.
When: Tuesday December 23, 2025 at 12:15 pm
Where: Lucas Oil Stadium
Bet: Bet On This Match HERE
Indianapolis Colts vs San Francisco 49ers Odds
Indianapolis Colts vs San Francisco 49ers Preview
Last weeks Phil Rivers experience was fun but not good football.
The Colts had done a great job of becoming a serious franchise this year and even changed our minds about Daniel Jones but this Phil Rivers at QB thing? You cant be serious.
49ers are going to show why the Colts shouldve gone and got a backup who had played in the last 5 years.
Content provided by Neds
Head To Head Bet
We're tipping San Francisco 49ers to win at $1.35 odds.