Houston Texans vs San Francisco 49ers Tips, Odds & Predictions – NFL 2025

NRG Stadium will play host to Monday's Round 8 NFL game between Houston Texans and San Francisco 49ers. The game kicks off at 4:00 am with Houston Texans heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Houston Texans vs. San Francisco 49ers game and give you our free tips and bets.

When: Monday October 27, 2025 at 4:00 am

Where: NRG Stadium

Bet 💰: Bet On This Match HERE

Houston Texans vs San Francisco 49ers Odds

Houston Texans vs San Francisco 49ers Preview

Punters are flocking to San Francisco already with the 49ers dropping from $2.10 to $1.94 a long way out from kickoff.

Despite an injury depleted roster, the 49ers are 5-2 and are (slight) outsiders against a 2-4 Texans team that appears to be sleepwalking through their schedule.

It sure looks like those two wins over the atrocious Titans and Ravens in back to back weeks were a false dawn and they can’t compete with even average teams.

Will happily jump on the 49ers and if they move into favouritism I’d be happy to bet them up to -2.5 without a second thought.

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Head To Head Bet

Houston Texans
$1.75
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We're tipping Houston Texans to win at $1.75 odds.

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