NRG Stadium will play host to Friday's Round 12 NFL game between Houston Texans and Buffalo Bills. The game kicks off at 12:15 pm with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Houston Texans vs. Buffalo Bills game and give you our free tips and bets.

When: Friday November 21, 2025 at 12:15 pm

Where: NRG Stadium

Bet 💰: Bet On This Match HERE

Houston Texans vs Buffalo Bills Odds

Houston Texans vs Buffalo Bills Preview

The Texans come into Friday night determined to prove they can compete without their star quarterback. With Davis Mills leading the offense, Houston will lean heavily on its disciplined defense and the electric playmaking of Nico Collins to keep pace. Their challenge will be sustaining long drives and avoiding costly mistakes against a high-pressure opponent.

Buffalo enters the matchup carrying momentum, driven by Josh Allen’s dual-threat brilliance. The Bills’ offense can score in bursts, and even with injuries limiting key weapons, Allen’s versatility keeps defenses guessing. Their goal will be to start fast, push the tempo, and force Houston out of its comfort zone early.

Both teams understand the stakes as the playoff race tightens. Houston seeks a statement win to stay alive in the hunt, while Buffalo aims to reinforce its status as a conference contender. Expect a physical, strategic battle where turnovers, red-zone efficiency, and late-game composure could decide the night.

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Houston Texans vs Buffalo Bills Tip