Ford Field will play host to Monday's Round 4 NFL game between Detroit Lions and Cleveland Browns. The game kicks off at 3:00 am with Detroit Lions heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Detroit Lions vs. Cleveland Browns game and give you our free tips and bets.

When: Monday September 29, 2025 at 3:00 am

Where: Ford Field

Bet 💰: Bet On This Match HERE

Detroit Lions vs Cleveland Browns Odds

Detroit Lions vs Cleveland Browns Preview

The Detroit Lions face the Cleveland Browns in a key matchup this week, with both sides looking to strengthen their playoff credentials. Detroit’s high-powered offense, led by Jared Goff and Amon-Ra St. Brown, will be tested by Cleveland’s elite defense anchored by Myles Garrett. The Browns’ success hinges on how well Deshaun Watson and the running game can control possession and limit the Lions’ scoring chances. It shapes as a classic battle of offense versus defense.