Empower Field at Mile High will play host to Monday's Round 3 NFL game between Denver Broncos and San Francisco 49ers. The game kicks off at 10:20 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Denver Broncos vs. San Francisco 49ers game and give you our free tips and bets.

When: Monday September 26, 2022 at 10:20 am

Where: Empower Field at Mile High

Bet 💰: Bet On This Match HERE

Denver Broncos vs San Francisco 49ers Odds

Denver Broncos vs San Francisco 49ers Preview

Denver might be experiencing a real case of buyer’s remorse on Russell Wilson so far, with the quarterback yet to impress in his new surroundings.

Meanwhile San Francisco has lucked into a much better scenario (for the short term at least) with the injury to Trey Lance forcing them to turn back to Jimmy Garoppolo.

That makes the 49ers a lot more dangerous in every game this season and Jimmy G is far better equipped to guide this roster through games like this.

If Denver’s struggles continue then this game could get very ugly with San Francisco a great chance of running away with it.

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Denver Broncos vs San Francisco 49ers Tip