Huntington Bank Field will play host to Monday's Round 13 NFL game between Cleveland Browns and San Francisco 49ers. The game kicks off at 5:00 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Cleveland Browns vs. San Francisco 49ers game and give you our free tips and bets.

When: Monday December 1, 2025 at 5:00 am

Where: Huntington Bank Field

Bet 💰: Bet On This Match HERE

Cleveland Browns vs San Francisco 49ers Odds

Cleveland Browns vs San Francisco 49ers Preview

The Cleveland Browns enter this showdown leaning on their bruising ground game and a defense built to create disruption. Their offense will look to establish physicality early, using power runs and timely play-action to challenge San Francisco’s disciplined front. If Cleveland can control possession, they’ll set the tone for a gritty contest.

The San Francisco 49ers counter with one of the league’s most balanced and efficient offenses, blending creative rushing schemes with a precise passing attack. Their playmakers in space pose a constant threat, and the Browns’ defense will need disciplined tackling to limit explosive gains. Defensively, the 49ers aim to use their speed and pressure to force Cleveland into uncomfortable situations.

This matchup may ultimately hinge on which team wins the line of scrimmage. The Browns rely on toughness and sustained drives, while the 49ers thrive on rhythm, efficiency, and timely bursts of big-play potential. With two physical teams colliding, fans can expect a high-intensity battle where momentum swings could decide the outcome.