Bank of America Stadium will play host to Monday's Round 8 NFL game between Carolina Panthers and Buffalo Bills. The game kicks off at 4:00 am with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Carolina Panthers vs. Buffalo Bills game and give you our free tips and bets.

When: Monday October 27, 2025 at 4:00 am

Where: Bank of America Stadium

Bet 💰: Bet On This Match HERE

Carolina Panthers vs Buffalo Bills Odds

Carolina Panthers vs Buffalo Bills Preview

Carolina is one of the biggest enigmas in the NFL, winning their last three and four of their last five but questions still remain over whether or not they are good.

Are we going to get the team that ran over Miami and Dallas or the one that had a no-show in New England?

No Bryce Young is worth taking note of, but there is not a huge drop off to Andy Dalton.

We know Buffalo is good, but they have been playing well below their expected level the last few weeks and the hope in western New York is that the bye week will help them straighten things out.

One of their biggest concerns is a run defence that has only really stopped the Jets so far this season, which is not a good lead in to face Rico Dowdle who has been one of the breakout players of the last month.

That line market looks about right and I like the Bills to win a close game, but Dowdle could be set for another big day on the ground as Carolina keeps it close.

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