Highmark Stadium will play host to Monday's Round 11 NFL game between Buffalo Bills and Tampa Bay Buccaneers. The game kicks off at 5:00 am with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Buffalo Bills vs. Tampa Bay Buccaneers game and give you our free tips and bets.
When: Monday November 17, 2025 at 5:00 am
Where: Highmark Stadium
Bet: Bet On This Match HERE
Buffalo Bills vs Tampa Bay Buccaneers Odds
Buffalo Bills vs Tampa Bay Buccaneers Preview
No matter which way you look at it, this game is going to be a lot of fun.
The Bills are coming off an awful performance in Miami last week where they suffered their third loss of the season and in a congested AFC playoff field that was a big blow.
On their day they remain one of the most unstoppable offences in the league but those days are few and far between.
Injuries have hit both of these teams hard although it looks like Tampa Bay might be in position to welcome back a few key contributors that missed last weeks loss to New England.
This game really will swing on the health and wellbeing of both rosters and Im going to stay away from the result market until we get closer to kickoff.
One player who has been a steady performer for the Bills though is James Cook who is in the midst of another strong season.
He has five 100 yard games but hasnt found the end zone in his last two outings, though the Buccaneers did give up a pair of long runs last week and Ill jump on Cook to have a big day.
Content provided by Ladbrokes
Head To Head Bet
We're tipping Buffalo Bills to win at $1.40 odds.