Highmark Stadium will play host to Monday's Round 4 NFL game between Buffalo Bills and New Orleans Saints. The game kicks off at 3:00 am with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Buffalo Bills vs. New Orleans Saints game and give you our free tips and bets.
When: Monday September 29, 2025 at 3:00 am
Where: Highmark Stadium
Bet: Bet On This Match HERE
Buffalo Bills vs New Orleans Saints Odds
Buffalo Bills vs New Orleans Saints Preview
The Buffalo Bills host the New Orleans Saints in a key matchup that pits one of the AFC’s top contenders against an improving NFC challenger. Josh Allen leads a high-powered Bills offense looking to bounce back from recent inconsistencies, while the Saints rely on a strong defense and the playmaking of Derek Carr and Alvin Kamara. Home-field advantage gives Buffalo the edge, but New Orleans has the weapons to make it a tight contest.
Head To Head Bet
We're tipping Buffalo Bills to win at $1.03 odds.