Caesars Superdome will play host to Friday's Round 12 NFL game between Buffalo Bills and New Orleans Saints. The game kicks off at 12:21 pm with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Buffalo Bills vs. New Orleans Saints game and give you our free tips and bets.

When: Friday November 26, 2021 at 12:21 pm

Where: Caesars Superdome

Bet 💰: Bet On This Match HERE

Buffalo Bills vs New Orleans Saints Odds

Buffalo Bills vs New Orleans Saints Preview

At full health this would be a proper blockbuster however injuries for the Saints make this a much more one sided contest on paper.

Buffalo might be struggling for consistency, alternating wins and losses over their last six games but they need this game in the worst possible way.

Half a game behind New England in the AFC East and coming off an embarrassing loss at home to Indianapolis, the Bills should come out firing.

Five of the last seven offensive touchdowns given up by New Orleans have been from quarterbacks rushing into the end zone and Josh Allen can move with the best of them.

Take Buffalo to cover as well as Allen to score a touchdown with his legs while also throwing for a couple of scores.

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Buffalo Bills vs New Orleans Saints Tip