Highmark Stadium will play host to Monday's Round 5 NFL game between Buffalo Bills and New England Patriots. The game kicks off at 11:20 am with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Buffalo Bills vs. New England Patriots game and give you our free tips and bets.

When: Monday October 6, 2025 at 11:20 am

Where: Highmark Stadium

Bet 💰: Bet On This Match HERE

Buffalo Bills vs New England Patriots Odds

Buffalo Bills vs New England Patriots Preview

AFC East Rivals face off in another lopsided match-up.

Bills are the only other 4-0 team and this should be as close as they let it be.

The line is 7.5 but I could see some garbage time touchdowns making it look closer than the game will be.

Cook is running mad right now, Allen is getting more and more warmed up through the air and he ran one in last week.

Bills all day.

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