Levi's stadium will play host to Monday's Round 1 NFL game between Arizona Cardinals and San Francisco 49ers. The game kicks off at 6:25 am with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Arizona Cardinals vs. San Francisco 49ers game and give you our free tips and bets.

When: Monday September 14, 2020 at 6:25 am

Where: Levi's stadium

Bet 💰: Bet On This Match HERE

Arizona Cardinals vs San Francisco 49ers Odds

Arizona Cardinals vs San Francisco 49ers Preview

The Arizona Cardinals will be hoping to create another headline this week with an upset win over the 49ers at Levi’s Stadium.

Arizona made a splash right before the draft by acquiring wide receiver DeAndre Hopkins in a trade that sent running back David Johnson packing to Houston.

As a result, the Cardinals are left with what appears to be one of the most talented offensive rosters in the league with offensive mastermind Kliff Kingsbury pulling the strings.

San Francisco, meanwhile, has spent the better part of six months wondering what could have been.

The Niners looked well on their way to winning the Lombardi Trophy last year before some questionable fourth quarter decisions got in the way.

Defensively, the Niners have what it takes to stifle the Cardinals, but one has to wonder if we’ll see another Super Bowl hangover unfold similar to the Falcons and Rams in recent years.

The Cardinals are firmly a contender for the NFC West and are easily the most improved team heading into the season.

Arizona gave the Niners a real scare on both occasions last year, so the fact we’re getting +7 at the line is quite remarkable.

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Arizona Cardinals vs San Francisco 49ers Tip