South Africa were bowled out for 517 in their first innings on the third day of the second and final Test against Pakistan in Dubai on Friday.
Resuming on 4-460, South Africa lost AB de Villiers for 164 and Graeme Smith for 234 after they put on a record 338-run partnership.
They took a huge 418-run lead over Pakistan’s first-innings total of just 99.
Pakistan offspinner Saeed Ajmal finished with 6-151 while paceman Mohammad Irfan took 3-102 after an extended two-and-a-half hour session due to Friday prayers.
Pakistan lead the two-match series 1-0 after winning last week’s first Test in Abu Dhabi by seven wickets.