Scotland captain Preston Mommsen won the toss and sent Australia in to bat in the one-day international at The Grange Cricket Club in Edinburgh on Tuesday.
Australia have named a strong side for the match, with Michael Clarke returning as captain following last week’s two Twenty20 internationals against England.
Adam Voges and Clint McKay are the other players included after missing the T20 games.
Former Pakistani refugee Fawad Ahmed earns his first ODI cap for Australia after impressing in the two T20s.
Aaron Finch and Shaun Marsh will open the batting for Australia after David Warner was omitted from the one-day squad while there was no place in the team for Phillip Hughes.
The one-off match precedes a five-game series against England for Australia while Scotland are using the match as a tune-up for two crucial 2015 World Cup qualifiers against Ireland.
Australia: Aaron Finch, Shaun Marsh, Shane Watson, Michael Clarke (capt), George Bailey (vc), Adam Voges, Matthew Wade, James Faulkner, Mitchell Johnson, Clint McKay, Fawad Ahmed.
Scotland: Freddie Coleman, Hamish Gardiner, Matt Machan, Calum MacLeod, Richie Berrington, Preston Mommsen (capt), Majid Haq, David Murphy, Gordon Goudie, Gordon Drummond, Iain Wardlaw.