South Africa have rested Jacques Kallis and included four uncapped players for the one-day series against New Zealand at the end of the month.
The 37-year-old veteran has spoken recently of his desire to manage his ODI appearances in order to make the 2015 World Cup.
Without him, wicketkeeper Quinton de Kock, spinner Aaron Phangiso, batsman Farhaan Behardien and seam bowler Rory Kleinveldt were called into a 14-man squad on Sunday for the three-game series.
All four have played Twenty20 cricket for South Africa, while Kleinveldt made his Test debut last year.
South Africa will play three ODIs against New Zealand and five against Pakistan before the Champions Trophy in England in June.
South Africa and New Zealand will clash next week in the second of two Tests.