Richmond could be without their AFL Big Four – captain Trent Cotchin, Dustin Martin, Jack Riewoldt and Alex Rance – for the first time since 2010.
With Rance and Riewoldt already sidelined through injury, Cotchin is also expected to be ruled out of Saturday’s away match against Port Adelaide.
Cotchin suffered a hamstring injury in last Saturday’s loss to GWS.
That leaves Martin, with the Tigers sweating on Monday afternoon’s match review findings.
He is under scrutiny for a hit well off the ball in the second term of Saturday’s clash at Giants Stadium.
The incident cost the Tigers a free kick and a goal.
Martin is in double trouble from the league after losing his cool in the match.
The AFL could ask Martin to explain a couple of incidents where he flipped the bird to an opponent and also imitated snorting drugs.
The speculation is that the drugs sledge was directed at Shane Mumford, who was suspended for the opening two games this season after a video emerged of him snorting white powder.
At worst, Martin could be suspended for the off-the-ball hit and also fined for the gestures.
Richmond have lost Rance for the rest of the season with a knee reconstruction, while Riewoldt has a wrist injury.
Since Martin made his AFL debut in round one of the 2010 season, members of the star quartet have always been in the Richmond senior team.
They had enjoyed a dream run with injuries – until Rance went down in round one, all of them had played at least 20 games per season since 2015.