Essendon have lost captain Dyson Heppell, Jake Stringer, Orazio Fantasia and Zac Clarke among six changes for the AFL blockbuster against Collingwood.
The Bombers regain Tom Bellchambers and Cale Hooker, while Tom Jok will make his debut on Friday night.
Steele Sidebottom is out because of surgery to repair a ruptured testicle and Darcy Moore will take his place.