Huntington Bank Field will play host to Monday's Round 16 NFL game between Cleveland Browns and Buffalo Bills. The game kicks off at 5:00 am with Buffalo Bills heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the Cleveland Browns vs. Buffalo Bills game and give you our free tips and bets.

When: Monday December 22, 2025 at 5:00 am

Where: Huntington Bank Field

Bet 💰: Bet On This Match HERE

Cleveland Browns vs Buffalo Bills Odds

Cleveland Browns vs Buffalo Bills Preview

Bills are now within ONE GAME in the AFC East race and being dished up the Browns is a gift from the football gods.

Browns are 3-12 after getting destroyed 31-3 by the Bears. Shedeur Sanders is getting reps but this team is cooked.

Bills to cruise and a lot of pressure on the Pats later this week

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