Levi's Stadium will play host to Tuesday's Round 12 NFL game between San Francisco 49ers and Carolina Panthers. The game kicks off at 12:15 pm with San Francisco 49ers heading into the game as favourites with the bookmakers. Continue reading for our in-depth preview of the San Francisco 49ers vs. Carolina Panthers game and give you our free tips and bets.

When: Tuesday November 25, 2025 at 12:15 pm

Where: Levi's Stadium

Bet 💰: Bet On This Match HERE

San Francisco 49ers vs Carolina Panthers Odds

San Francisco 49ers vs Carolina Panthers Preview

The San Francisco 49ers enter this matchup looking to impose their trademark physicality, leaning on a balanced offense fueled by precise quarterback play and a powerful run game. Their defense, anchored by a dominant front, will aim to pressure Carolina early and disrupt any rhythm before it begins.

The Carolina Panthers counter with a young roster eager to prove its growth, turning to a dynamic backfield and improving passing attack to challenge San Francisco’s disciplined unit. Defensively, Carolina’s focus will be on containing the 49ers’ explosive skill players and forcing them into tough third-down spots.

With contrasting levels of experience but equal determination, this clash promises a battle of execution and resilience. Expect momentum swings driven by big defensive plays and creative offensive bursts, setting up a final stretch where one decisive drive could define the outcome.