Ryan Harrison avoided a Brisbane International meltdown to rally from one set down and beat German lucky loser Yannick Hanfmann for a spot in the quarter-finals.

Angered by the music coming from the nearby centre court, the frustrated world No.47 went down a break in a first set he eventually lost in a tie-break.

But as the music eventually faded, lucky loser Hanfmann – beaten in qualifying but handed the injured Andy Murray’s place in the second round – could not complete the job on Thursday.

Harrison composed himself in the second set, saving three break points before breaking himself in a decisive swing and eventually prevailing 6-7 (5-7) 6-4 6-2.

The American will play Denis Istomin in the quarter-finals, after the Uzbek eased past American Jared Donaldson 7-6 (7-5) 6-2 earlier in the day.

Kyle Edmund then battled past South Korean Hyeon Chung in a two-hour 38 minute exchange 7-6 (7-3) 5-7 6-4.

The 22-year-old, who prevailed in a bruising three-set first round with Denis Shapovalov, will meet either top seed Grigor Dimitrov or Australian John Millman in the quarter-finals.

Edmund was able to steal back momentum after Chung pounced late to force a third set.

“I made an effort to really try and step up the intensity and energy and put some pressure on him,” Edmund said.

“The way I was serving in that third set, I knew if I got a break I was going to have a very good chance at holding out.”

The British No.2 will fly the flag into the Australian Open in the absence of Andy Murray, who announced his withdrawal from Melbourne earlier on Thursday because of a hip injury.

“You would like to see him playing but, unfortunately, he hasn’t been around the last six months,” Edmund said.

“I’m still pretty young, so every tournament I go back to, I’m trying to get better and better.

“Definitely my best tennis is ahead of me.”

There are only two seeded players left in the depleted men’s singles in Brisbane and both are on the other side of the draw – defending champion Dimitrov and Australia’s Nick Kyrgios.