Two-time Grand Slam runner-up Vera Zvonareva has withdrawn from next week’s US Open because of a viral illness.

The 16th-ranked Russian lost in the final at Flushing Meadows in 2010 to Kim Clijsters.

She retired in her third-round match against Clijsters at Wimbledon this year because of illness, then was routed 6-1 6-0 by Serena Williams in the round of 16 at the Olympics.

This will be the second major tournament missed this year by Zvonareva. She pulled out of the French Open because of a right shoulder injury.

Ranked as high as No.2 in the world in her career, Zvonareva also reached the final at Wimbledon in 2010.