Thanasi Kokkinakis has crashed out of the ATP Cincinatti Masters after going down 7-6 (7-5) 6-2 to in-form Frenchman Richard Gasquet.
Gasquet, who beat Kokkinakis’ Australian Davis Cup teammate Nick Kyrgios in the opening round on Tuesday, will now face US Open champion Marin Cilic in the third round.
French Open champion Stan Wawrinka came from a set down to beat teenaged Croatian Borna Coric 3-6 7-6 (7-3) 6-3.
The fifth-seeded Swiss initially struggled on a day when play began an hour late due to rain, but quickly recovered in the second set.
Enigmatic Pole Jerzy Janowicz advanced over American Jared Donaldson 6-4 7-6 (7-4).
In the women’s second round, Italian Karin Knapp beat Melbourne-based Russian Daria Gavrilova 6-4 6-1 while former world No.1 Jelena Jankovic left American Madison Keys a tearful wreck during and after a 7-6 (7-4) 6-4 second-round win.
Keys was seen sobbing at mid-match during a coaching conference with Lindsay Davenport and was again caught after the loss with her face buried in a towel in a busy hallway outside the locker room.
The 19th-ranked Keys has won just two matches since achieving a Wimbledon quarter-final.