Australian big guns Nick Kyrgios and Bernard Tomic could potentially meet in the third round of the US Open.

Kyrgios, who has never lost to a lower-ranked or unseeded player at a grand slam event, is seeded 14th for the final major of 2016 and will be confident of extending that record against Slovenian-born Briton Aljaz Bedene in the first round.

Tomic, fresh off his win over 2014 runner-up Kei Nishikori in Cincinnati last week, has been seeded 17th and meets Bosnia’s Damir Dzumhur in the opening round for the second year in succession.

The 17th seed prevailed in four sets last year at Flushing Meadows.

John Millman, who chalked up the biggest win of his career against Richard Gasquet at the Winston-Salem Open in North Carolina on Thursday, has been handed a tough opener against world No.10 Dominic Thiem.

Sydney’s Jordan Thompson meets Dimitry Tursunov with wildcard James Duckworth drawn against world No.64 Robin Hasse of The Netherlands.

Former champion Sam Stosur, seeded 16, takes on Italy’s Camilla Giorgi with Daria Gavrilova handed a tough draw.

Gavrilova will face 2015 French Open finalist Lucie Safarova in the first round, before a potential second round encounter with Romanian fifth seed Simona Halep.

Stosur could face a fourth-round showdown with Serena Williams, who she beat in the 2011 US Open final to win her solitary grand slam.

Ellen Perez, a 20-year-old from Wollongong who was awarded a wildcard, meets Shuai Zhang of China.