The matches involving Champions League winners Chelsea and Barclays Premier League champions Manchester City will open the new campaign live on television.
The Blues’ visit to Wigan on Sunday, August 19, will be the first of 42 top-flight games to be screened by Sky Sports between the start of the season and November, the broadcaster confirmed on Thursday.
They will be closely followed by City, who host promoted Southampton later the same day, with Manchester United in action against Everton at Goodison Park the following evening.
Every Premier League club will be featured at least twice, while the list of games includes five major derbies from the midlands, north London, Tyne and Wear, Merseyside and the north west.
Barney Francis, managing director of Sky Sports, said: “We’re all looking forward to the start of the Premier League and we begin with a bang; Champions League winners Chelsea, Premier League Champions Manchester City and Manchester United all in our opening weekend.”
Play-off winners West Ham will feature for the first time when they travel to Swansea on August 25, while Reading entertain Tottenham three weekends later.
Liverpool host Manchester United and Arsenal visit City on Sunday, September 23, while the Gunners will welcome Chelsea to the Emirates Stadium the following Saturday.
Sunderland will attempt to gain revenge for their derby defeat last season when Newcastle return to the Stadium of Light on Sunday, October 21, a day after Tottenham boss Andre Villas-Boas attempts to gain revenge on former employers Chelsea at White Hart Lane, while the first Merseyside derby takes place at Goodison the following Saturday.
A day later, United renew hostilities with Chelsea at Stamford Bridge and then face Arsenal at Old Trafford on Saturday, November 3.
The Emirates will stage the north London derby on Saturday, November 17, while new Liverpool boss Brendan Rodgers will return to former club Swansea the following weekend.
Meanwhile, ESPN will launch their program of Saturday evening kick-offs on Tyneside on August 18 when Spurs head to Newcastle, who also feature the following weekend in a tough trip to Chelsea.
United host Spurs on September 29, while derby rivals City’s visit to West Ham will be screened on November 3.
